794572-10-4
Chemical Structure
ML-184
Synonym(s): CID2440433
- CAS No.: 794572-10-4
- Formula:C25H34N4O3S
- Molecular Weight:470.63
IUPAC Name: 3-(4-(2,3-dimethylphenyl)piperazine-1-carbonyl)-N,N-dimethyl-4-(pyrrolidin-1-yl)benzenesulfonamide
InChIKey: VRSJAHQGJHDACS-UHFFFAOYSA-N
SMILES: CC1=CC=CC(N2CCN(CC2)C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)=C1C
Biological Activity: ML-184 (CID244033) is a selective GPR55 agonist with an EC50 of 250 nM, more than 100-fold selectivity for GPR55 over GPR35, CB1, and CB2. ML-184 induces ERK1/2 phosphorylation and PKCβII translocation to the plasma membrane via activation of GPR55. ML-184 (CID2440433) increases the proliferation of neural stem cells and promotes neuronal differentiation in vitro[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML-184 | 99.57% | ML-184 (CID244033) is a selective GPR55 agonist with an EC50 of 250 nM, more than 100-fold selectivity for GPR55 over GPR35, CB1, and CB2. ML-184 induces ERK1/2 phosphorylation and PKCβII translocation to the plasma membrane via activation of GPR55. ML-184 (CID2440433) increases the proliferation of neural stem cells and promotes neuronal differentiation in vitro. | ||||||||||||||||||||
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References
- [1]. Kotsikorou E, et al. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47. [Content Brief]
- [2]. Hill JD, et al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175(16):3407-3421. [Content Brief]
- [3]. Corbett Reece, et al. Once-daily oral administration of gpr55 agonist ml-184 has direct and indirect benefits on [beta]-cell and gastrointestinal health in obese-diabetic mice. Endocrine Abstracts. Vol. 104. Bioscientifica, 2024.
