79573-48-1
79573-48-1
Chemical Structure
Mefox
- CAS No.: 79573-48-1
- Formula:C20H23N7O7
- Molecular Weight:473.44
IUPAC Name: (4-(((2-amino-8-methyl-4,9-dioxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a][1,3,5]triazin-7-yl)methyl)amino)benzoyl)-L-glutamic acid
InChIKey: AFIMZPFBSYESNQ-ABLWVSNPSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C)C(C(N3C2)=NC(N)=NC3=O)=O)C=C1)=O
Biological Activity: Mefox is a biologically inactive oxidation product of 5-MTHF (HY-113046). Mefox is a stable biomarker of folate metabolism and oxidative stress. Mefox is used as a B vitamin standard for UHPLC-SRM MS quantification[1][2][3][4][5][6][7][8][9].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mefox | 99.89% | Mefox is a biologically inactive oxidation product of 5-MTHF (HY-113046). Mefox is a stable biomarker of folate metabolism and oxidative stress. Mefox is used as a B vitamin standard for UHPLC-SRM MS quantification. | ||||||||||||||||||||
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References
- [1]. Ringling C, et al. Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate. Nutrients. 2017 Sep 01;9(9):969.
- [2]. Zhang H, et al. Validated B vitamin quantification from lentils by selected reaction monitoring mass spectrometry. Food chemistry. 2021 Oct 15;359:129810.
- [3]. Shahid M, et al. Folate monoglutamate in cereal grains: Evaluation of extraction techniques and determination by LC-MS/MS. Journal of Food Composition and Analysis. 2020 Aug 1;91:103510.
- [4]. Rudolf Moser, et al. Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid. Patent, WO2018178144A1.
- [5]. Liang Q, et al. Creation of folate-biofortified rice by simultaneously enhancing biosynthetic flux and blocking folate oxidation. Molecular Plant. 2024 Oct 7;17(10):1487-9.
- [6]. Lian T, et al. An Allele of Glutamate Formiminotransferase Triggers 5-Methyl-Tetrahydrofolate-to-MeFox Conversion and Facilitates Folate Biofortification in Maize. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 Nov;12(42):e15082.
- [7]. Heughebaert L, et al. Is the stability of folates in dried blood microsamples sufficient to perform home-sampling studies?. The Analyst. 2024 Jan 29;149(3):895-908.
- [8]. Fang YW, et al. Glyphosate Exposure, Oxidative Stress, Mitochondrial Dysfunction, and Mortality Risk in US Adults: Insights from the National Health and Nutrition Examination Survey. Toxics. 2025 May 04;13(5):373.
- [9]. Munezero E, et al. Identifying the Safe and Adequate Folic Acid Intake Range Using Biomarkers in 2 Mouse Models. The Journal of nutrition. 2025 Dec;155(12):4320-4330.
