79786-01-9
Chemical Structure
Casuarinin
- CAS No.: 79786-01-9
- Formula:C41H28O26
- Molecular Weight:936.65
InChIKey: MMQXBTULXAEKQE-VSLJGAQWSA-N
SMILES: OC1=C(O)C(O)=C(C2=C(C(O3)=O)C=C(O)C(O)=C2O)C(C(OC[C@@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@@H]3[C@H](OC(C5=C6C(O)=C(O)C(O)=C5)=O)[C@@H](O7)[C@@H](O)C8=C(C6=C(O)C(O)=C8O)C7=O)=O)=C1
Biological Activity: Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Casuarinin | 99.19% | Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections. | ||||||||||||||||||||
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References
- [1]. Kuo PL, et al. Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells. Planta Med. 2005;71(3):237-243. [Content Brief]
- [2]. Kwon DJ, et al. Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells. Biochem Biophys Res Commun. 2011;409(4):780-785. [Content Brief]
- [3]. Al-Sayed E, et al. Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats. Planta Med. 2020;86(1):32-44. [Content Brief]
- [4]. Souza-Moreira TM, et al. Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study. Molecules. 2013;18(7):8095-8108. Published 2013 Jul 9. [Content Brief]
- [5]. Cheng HY, et al. Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn. Antiviral Res. 2002;55(3):447-455. [Content Brief]
