808756-71-0
808756-71-0
Chemical Structure
ABT-102
- CAS No.: 808756-71-0
- Formula:C21H24N4O
- Molecular Weight:348.44
IUPAC Name: (R)-1-(5-(tert-butyl)-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea
InChIKey: TYOYXJNGINZFET-GOSISDBHSA-N
SMILES: O=C(NC1=CC=CC2=C1C=NN2)N[C@@H]3CCC4=C3C=CC(C(C)(C)C)=C4
Biological Activity: ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ABT-102 | 98.50% | ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain. | ||||||||||||||||||||
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References
- [1]. Lukin K, et al. Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102. Organic Process Research & Development, 2007, 11(3):578-584.
- [2]. Rowbotham MC, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011 May;152(5):1192-1200. [Content Brief]
