81-04-9
Chemical Structure
1,5-Naphthalenedisulfonic acid
Synonym(s): Armstrong's acid
- CAS No.: 81-04-9
- Formula:C10H8O6S2
- Molecular Weight:288.30
IUPAC Name: naphthalene-1,5-disulfonic acid
InChIKey: XTEGVFVZDVNBPF-UHFFFAOYSA-N
SMILES: O=S(O)(C1=C(C=CC=C2S(=O)(O)=O)C2=CC=C1)=O
Biological Activity: 1,5-Naphthalenedisulfonic acid (Armstrong's acid) is an aromatic disulfonic acid compound commonly used as an intermediate in the dye industry and organic synthesis. 1,5-Naphthalenedisulfonic acid is a pharmaceutical co-former that significantly improves the solubility and thermodynamic stability of poorly soluble drugs. 1,5-Naphthalenedisulfonic acid constructs a stable supramolecular network through coordination, hydrogen bonding, and electrostatic interactions, thereby effectively preventing drug crystallization. 1,5-Naphthalenedisulfonic acid exhibits certain cytotoxicity and antitumor activity in some human hepatoma cells. 1,5-Naphthalenedisulfonic acid can be used for research on human hepatoma[1][2][3][4][5][6].
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1,5-Naphthalenedisulfonic acid | 1,5-Naphthalenedisulfonic acid (Armstrong's acid) is an aromatic disulfonic acid compound commonly used as an intermediate in the dye industry and organic synthesis. 1,5-Naphthalenedisulfonic acid is a pharmaceutical co-former that significantly improves the solubility and thermodynamic stability of poorly soluble drugs. 1,5-Naphthalenedisulfonic acid constructs a stable supramolecular network through coordination, hydrogen bonding, and electrostatic interactions, thereby effectively preventing drug crystallization. 1,5-Naphthalenedisulfonic acid exhibits certain cytotoxicity and antitumor activity in some human hepatoma cells. 1,5-Naphthalenedisulfonic acid can be used for research on human hepatoma. | |||||||||||||||||||||
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References
- [1]. Singh N, et al. Synthesis, structural, solubility and anticancer activity studies of salts using nucleobases and sulfonic acids coformer. Journal of Molecular Structure. 2017 Oct 15;1146:703-12.
- [2]. Tai XS, et al. Synthesis, crystal structure and antitumor activity of Ca (II) coordination polymer based on 1, 5-naphthalenedisulfonate. Journal of Inorganic and Organometallic Polymers and Materials. 2013 Nov;23(6):1354-7.
- [3]. Tai XS, et al. Synthesis, crystal structure and antitumor activity of a dinuclear calcium complex based on 1,5-naphthalenedisulfonate and 2,2′-bipyridine ligands. Res Chem Intermed. 2015;41:4339-47.
- [4]. Ravera M, et al. Oxidative degradation of 1,5-naphthalenedisulfonic acid in aqueous solutions by UV-photolysis in the absence and presence of H2O2. Chemosphere. 2010 Mar;79(2):144-8.
- [5]. Jin S, et al. Crystal and molecular structures of three salts from aliphatic amines (2,4-dichlorophenoxy)-acetic acid, 4-nitrophthalic acid, and 1,5-naphthalenedisulfonic acid. J Chem Crystallogr. 2015;45:495-503.
- [6]. Kim SY, et al. Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice. Pharmaceutics. 2023 Sep 04;15(9):2277. [Content Brief]
