81043-56-3
Chemical Structure
Metrenperone
- CAS No.: 81043-56-3
- Formula:C24H26FN3O2
- Molecular Weight:407.48
IUPAC Name: 3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one
InChIKey: AXQRPYKSPHUOGZ-UHFFFAOYSA-N
SMILES: O=C1C(CCN2CCC(CC2)C(C3=CC=C(C=C3)F)=O)=C(N=C4N1C=C(C=C4)C)C
Biological Activity: Metrenperone is an inhibitor for 5-HT2 receptor. Metrenperone exhibits α1 and α2 antagonist activity as well as anti-H1 and anti-dopaminergic efficacy. Metrenperone can lower the blood pressure, enhances bradycardia in peripheral ischemia, inhibits serotonin-induced platelet aggregation, and antagonizes serotonin-mediated vasoconstriction. Metrenperone promotes the repair of acutely damaged collagen tissue[1][2].
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Metrenperone | Metrenperone is an inhibitor for 5-HT2 receptor. Metrenperone exhibits α1 and α2 antagonist activity as well as anti-H1 and anti-dopaminergic efficacy. Metrenperone can lower the blood pressure, enhances bradycardia in peripheral ischemia, inhibits serotonin-induced platelet aggregation, and antagonizes serotonin-mediated vasoconstriction. Metrenperone promotes the repair of acutely damaged collagen tissue. | |||||||||||||||||||||
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References
- [1]. Oryan A, et al., Effects of a serotonin S2-receptor blocker on healing of acute and chronic tendon injuries. J Invest Surg. 2009 Jul-Aug;22(4):246-55. [Content Brief]
- [2]. Linden A, et al., Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Vet J. 1999 Jan;157(1):31-7. [Content Brief]
