81702-42-3
81702-42-3
Chemical Structure
(R)-SKF 38393 hydrochloride
Synonym(s): (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride
- CAS No.: 81702-42-3
- Formula:C16H18ClNO2
- Molecular Weight:291.77
IUPAC Name: (R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
InChIKey: YEWHJCLOUYPAOH-PFEQFJNWSA-N
SMILES: OC1=C(C=C2[C@H](CNCCC2=C1)C3=CC=CC=C3)O.Cl
Biological Activity: (R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].
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(R)-SKF 38393 hydrochloride | (R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel. | |||||||||||||||||||||
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References
- [1]. Kuzhikandathil EV, et, al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26. [Content Brief]
