817194-38-0
817194-38-0
Chemical Structure
GSK180736A
- CAS No.: 817194-38-0
- Formula:C19H16FN5O2
- Molecular Weight:365.36
IUPAC Name: 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
InChIKey: HEAIGWIZTYAQTC-UHFFFAOYSA-N
SMILES: CC(N1)=C(C(NC2=CC=C(NN=C3)C3=C2)=O)C(C4=CC=C(F)C=C4)NC1=O
Biological Activity: GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK180736A | 98.81% | GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM. | ||||||||||||||||||||
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