81760-46-5
Chemical Structure
Cafestol palmitate
- CAS No.: 81760-46-5
- Formula:C36H58O4
- Molecular Weight:554.84
IUPAC Name: ((3bS,5aS,7R,8R,10aR,10bS)-7-hydroxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-yl)methyl palmitate
InChIKey: DGPMHJKMSANHDM-SMDVAALKSA-N
SMILES: C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)CC2)C[C@](CC3)([H])[C@](O)(C4)COC(CCCCCCCCCCCCCCC)=O
Biological Activity: Cafestol palmitate is an orally active diterpene ester. Cafestol palmitate can be isolated from raw coffee beans. Cafestol palmitate enhances the activity of Glutathione S-transferase. Cafestol palmitate downregulates the expression of Akt and VEGFR2. Cafestol palmitate can be used in the research of inflammatory diseases and cardiovascular diseases[1][2][3].
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Cafestol palmitate | Cafestol palmitate is an orally active diterpene ester. Cafestol palmitate can be isolated from raw coffee beans. Cafestol palmitate enhances the activity of Glutathione S-transferase. Cafestol palmitate downregulates the expression of Akt and VEGFR2. Cafestol palmitate can be used in the research of inflammatory diseases and cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Lam LK, et al. Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. Cancer Res. 1982 Apr;42(4):1193-8. [Content Brief]
- [2]. Ren Y, et al. Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. International journal of molecular sciences. 2019 Aug 30;20(17):4238.
- [3]. Muhammad I, et al. COX-2 inhibitory activity of cafestol and analogs from coffee beans[J]. Natural Product Communications, 2008, 3(1): 1934578X0800300103.
