81840-57-5
Chemical Structure
Yakuchinone B
- CAS No.: 81840-57-5
- Formula:C20H22O3
- Molecular Weight:310.39
InChIKey: OKVCTOBWIAGOMR-ACCUITESSA-N
SMILES: O=C(CCCCC1=CC=CC=C1)/C=C/C2=CC(OC)=C(C=C2)O
Biological Activity: Yakuchinone B is an orally active and potent 5-LOX and COX-1/2 inhibitor with IC50 values of 0.37, 53.9, and 42 μM, respectively, and can be isolated and extracted from Alpinia oxyphylla. Yakuchinone B exhibits anti-inflammatory, antioxidant, and antitumor activities. Yakuchinone B exerts anti-inflammatory protective effects by inhibiting 5-LOX/COX activity and AP-1 DNA binding, downregulating the expression of pro-inflammatory factors, and modulating the gut microbiota metabolic axis to promote short-chain fatty acid production. Yakuchinone B can be used for research on colitis and cancer[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Yakuchinone B | 99.58% | Yakuchinone B is an orally active and potent 5-LOX and COX-1/2 inhibitor with IC50 values of 0.37, 53.9, and 42 μM, respectively, and can be isolated and extracted from Alpinia oxyphylla. Yakuchinone B exhibits anti-inflammatory, antioxidant, and antitumor activities. Yakuchinone B exerts anti-inflammatory protective effects by inhibiting 5-LOX/COX activity and AP-1 DNA binding, downregulating the expression of pro-inflammatory factors, and modulating the gut microbiota metabolic axis to promote short-chain fatty acid production. Yakuchinone B can be used for research on colitis and cancer. | ||||||||||||||||||||
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References
- [1]. Hsu JY, et al. Synthesis of Yakuchinone B-Inspired Inhibitors against Islet Amyloid Polypeptide Aggregation. Journal of natural products. 2021 Apr 23;84(4):1096-1103.
- [2]. Yamazaki R, et al. Anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative, on dermal inflammation in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1998 Apr;47(4):182-6.
- [3]. Yamazaki R, et al. Diarylheptanoids suppress expression of leukocyte adhesion molecules on human vascular endothelial cells. European journal of pharmacology. 2000 Sep 22;404(3):375-85.
- [4]. Chun KS, et al. Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. Mutation research. 1999 Jul 16;428(1-2):49-57.
- [5]. Zhang Q, et al. Anti-proliferative and pro-apoptotic activities of Alpinia oxyphylla on HepG2 cells through ROS-mediated signaling pathway. Journal of ethnopharmacology. 2015 Jul 01;169:99-108.
- [6]. Wang Y, et al. Yakuchinone B Ameliorates DSS-Induced Colitis by Modulating the Gut Microbiota-Metabolite Axis. Nutrients. 2026 Aug 12;18(16):2628.
- [7]. Sur B, et al. Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway. Inflammation. 2019 Jun;42(3):1093-1102.
- [8]. Sehgal A, et al. Synthesis of novel derivatives of yakuchinone B as promising anti-inflammatory agents. Afr J Biol Sci. 2024;6(4):1237-1277.
