81907-63-3
Chemical Structure
Methyl ganoderate A
Synonym(s): Ganoderic acid A methyl ester
- CAS No.: 81907-63-3
- Formula:C31H46O7
- Molecular Weight:530.69
InChIKey: GBFBBVYGZAABTI-YKJQFONZSA-N
SMILES: C[C@]12C3=C(C(C[C@@]1([C@@](C[C@@H]2O)([H])[C@H](C)CC(C[C@@H](C)C(OC)=O)=O)C)=O)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])C[C@@H]3O)C
Biological Activity: Methyl ganoderate A (Ganoderic acid A methyl ester) is a triterpenoid derivative. Methyl ganoderate A can be isolated from the fruiting bodies of G. lucidum. Methyl ganoderate A selectively inhibits CLK2 with an IC50 of 0.69 μM. Methyl ganoderate A inhibits the expression of ADAMTS5, MMP3, and MMP13, and reduces the levels of the cytokines IL-6, TNF-α, and IL-1β. Methyl ganoderate A can be used in research on knee osteoarthritis, Alzheimer's disease, and neuroinflammation[1][2][3][4][5].
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Methyl ganoderate A | Methyl ganoderate A (Ganoderic acid A methyl ester) is a triterpenoid derivative. Methyl ganoderate A can be isolated from the fruiting bodies of G. lucidum. Methyl ganoderate A selectively inhibits CLK2 with an IC50 of 0.69 μM. Methyl ganoderate A inhibits the expression of ADAMTS5, MMP3, and MMP13, and reduces the levels of the cytokines IL-6, TNF-α, and IL-1β. Methyl ganoderate A can be used in research on knee osteoarthritis, Alzheimer's disease, and neuroinflammation. | |||||||||||||||||||||
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References
- [1]. Zhang X, et al. Discovery of triterpenoid derivatives as novel selective CDC2-like kinase 2 inhibitors against knee osteoarthritis. Journal of Chemical Research. 2025 May;49(3):17475198251338527.
- [2]. Lee S, et al. Natural inhibitors for protein prenyltransferase. Planta medica. 1998 May;64(4):303-8.
- [3]. Lee I, et al. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorganic & medicinal chemistry letters. 2011 Nov 01;21(21):6603-7. [Content Brief]
- [4]. Ayral-Kaloustian S, et al. Protein farnesyltransferase inhibitors. Current medicinal chemistry. 2002 May 1;9(10):1003-32.
- [5]. Li DW, et al. Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH. Phytochemistry. 2022 Nov;203:113339.
