82131-82-6
Chemical Structure
H-77
- CAS No.: 82131-82-6
- Formula:C52H74N12O9
- Molecular Weight:1011.24
IUPAC Name: ((S)-2-((S)-2-((S)-2-((S)-1-(D-histidyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-3-(1H-imidazol-5-yl)propanamido)-4-methylpentyl)-L-leucyl-L-valyl-L-tyrosine
InChIKey: ABDWINSTWUZFIV-RLWIUDPYSA-N
SMILES: C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CN=CN2)C(N[C@H](CN[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(O)=O)=O)C(C)C)=O)CC(C)C)CC(C)C)=O)=O)(=O)[C@H]4N(C([C@@H](CC5=CN=CN5)N)=O)CCC4
Biological Activity: H-77 is a selective Renin inhibitor with an IC50 of 1.2 μM. H-77 causes dose-dependent decreases in plasma angiotensin I, plasma angiotensin II, and mean arterial pressure in sodium-depleted conscious beagle dogs. H-77 does not alter blood pressure or plasma angiotensin II levels in conscious chronically cannulated rats. H-77 can be used in studies related to the physiological and pathological states of the renin-angiotensin system[1][2][3].
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H-77 | H-77 is a selective Renin inhibitor with an IC50 of 1.2 μM. H-77 causes dose-dependent decreases in plasma angiotensin I, plasma angiotensin II, and mean arterial pressure in sodium-depleted conscious beagle dogs. H-77 does not alter blood pressure or plasma angiotensin II levels in conscious chronically cannulated rats. H-77 can be used in studies related to the physiological and pathological states of the renin-angiotensin system. | |||||||||||||||||||||
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References
- [1]. Szelke M, et al. H-77: a potent new renin inhibitor. In vitro and in vivo studies. Hypertension (Dallas, Tex. : 1979). 1982;4(3 Pt 2):59-69. [Content Brief]
- [2]. LECKIE B J, et al. Human renin inhibitors[J]. 1985.
- [3]. McIntyre GD, et al. Purification of human renin by affinity chromatography using a new peptide inhibitor of renin, H.77 (D-His-Pro-Phe-His-LeuR-Leu-Val-Tyr). Biochem J. 1983 May 1;211(2):519-22. [Content Brief]
