82310-93-8
82310-93-8
Chemical Structure
Hypusine dihydrochloride
- CAS No.: 82310-93-8
- Formula:C10H25Cl2N3O3
- Molecular Weight:306.23
IUPAC Name: N6-((R)-4-amino-2-hydroxybutyl)-L-lysine dihydrochloride
InChIKey: UTSZZUVUESAPQD-BPRGXCPLSA-N
SMILES: O=C([C@H](CCCCNC[C@@H](CCN)O)N)O.Cl.Cl
Biological Activity: Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A). Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety[1][2].
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Hypusine dihydrochloride | Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A). Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety. | |||||||||||||||||||||
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References
- [1]. Park MH, et al. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation. J Biol Chem. 2018 Nov 30;293(48):18710-18718. [Content Brief]
- [2]. Beninati S, et al. Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells. FEBS Lett. 1998 Oct 16;437(1-2):34-8. [Content Brief]
