824983-90-6
824983-90-6
Chemical Structure
FEN1-IN-7
- CAS No.: 824983-90-6
- Formula:C16H14N2O6S
- Molecular Weight:362.36
InChIKey: QSJHVKLMLSCTRZ-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(CC3=CC(OC)=C4OCOC4=C3)C(N1O)=O)SC=C2C
Biological Activity: FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].
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FEN1-IN-7 | 99.93% | FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents. | ||||||||||||||||||||
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