827344-05-8
827344-05-8
Chemical Structure
CS-0777
- CAS No.: 827344-05-8
- Formula:C21H30N2O2
- Molecular Weight:342.48
IUPAC Name: (R)-1-(5-(3-amino-4-hydroxy-3-methylbutyl)-1-methyl-1H-pyrrol-2-yl)-4-(p-tolyl)butan-1-one
InChIKey: YXEQXPNSBUIRDZ-OAQYLSRUSA-N
SMILES: CN1C(CC[C@@](CO)(C)N)=CC=C1C(CCCC2=CC=C(C)C=C2)=O
Biological Activity: CS-0777 is a selective, orally active sphingosine 1-phosphate receptor-1 modulator. CS-0777 can be used in the research of autoimmune diseases[1][2].
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CS-0777 | CS-0777 is a selective, orally active sphingosine 1-phosphate receptor-1 modulator. CS-0777 can be used in the research of autoimmune diseases. | |||||||||||||||||||||
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References
- [1]. Inaba SI, Yamaguchi-Goto M, Tanaka-Takanaka K, Yonesu K, Sakurai H, Kubota K, Izumi T. Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans. Xenobiotica. 2018 Mar;48(3):258-268. [Content Brief]
- [2]. Moberly JB, et al. Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. J Neuroimmunol. 2012 May 15;246(1-2):100-7. [Content Brief]
