83088-28-2
Chemical Structure
Gigantol
- CAS No.: 83088-28-2
- Formula:C16H18O4
- Molecular Weight:274.31
IUPAC Name: 3-(2-oxo-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimidine-4-carboxamido)benzoic acid
InChIKey: BMSPEISBKGSBTR-UHFFFAOYSA-N
SMILES: OC1=CC(CCC2=CC=C(C(OC)=C2)O)=CC(OC)=C1
Biological Activity: Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gigantol | 99.79% | Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury. | ||||||||||||||||||||
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References
- [1]. Losuwannarak N, et al. Gigantol Targets MYC for Ubiquitin-proteasomal Degradation and Suppresses Lung Cancer Cell Growth. Cancer Genomics Proteomics. 2020;17(6):781-793. [Content Brief]
- [2]. Chen P, et al. Gigantol exerts anti-lung cancer activity by inducing ferroptosis via SLC7A11-GPX4 axis. Biochem Biophys Res Commun. 2024;690:149274. [Content Brief]
- [3]. Huang Y, et al. Gigantol restores the sensitivity of mcr carrying multidrug-resistant bacteria to colistin. Phytomedicine. 2023;117:154886. [Content Brief]
- [4]. Xue Y, et al. Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway. Sci Rep. 2020 Dec 17;10(1):22265. [Content Brief]
- [5]. Basque A, et al. Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells. Curr Issues Mol Biol. 2021;44(1):73-93. Published 2021 Dec 23. [Content Brief]
