83162-84-9
Chemical Structure
Bonducellin
- CAS No.: 83162-84-9
- Formula:C17H14O4
- Molecular Weight:282.29
IUPAC Name: (E)-7-hydroxy-3-(4-methoxybenzylidene)chroman-4-one
InChIKey: DLQSYZMPSWHYMW-XYOKQWHBSA-N
SMILES: O=C1/C(COC2=CC(O)=CC=C12)=C/C3=CC=C(OC)C=C3
Biological Activity: Bonducellin is an efflux pump inhibitor and an EthD bromide (HY-D0021) sensitivity modulator. Bonducellin inhibits angiogenesis, proliferation, migration, and colony formation by regulating MMP9 gene expression, inhibiting iNOS and TNF-α/IL-12 production, inducing apoptosis, and targeting METTL3. Bonducellin can be used in research on tuberculosis, polycystic ovary syndrome, and colorectal cancer[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bonducellin | 99.33% | Bonducellin is an efflux pump inhibitor and an EthD bromide (HY-D0021) sensitivity modulator. Bonducellin inhibits angiogenesis, proliferation, migration, and colony formation by regulating MMP9 gene expression, inhibiting iNOS and TNF-α/IL-12 production, inducing apoptosis, and targeting METTL3. Bonducellin can be used in research on tuberculosis, polycystic ovary syndrome, and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Roy SK, et al. 7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc² 155. European journal of medicinal chemistry. 2013 Aug;66:499-507. [Content Brief]
- [2]. Karthikeyan M, et al. An integrated network pharmacological approach unveils the therapeutic mechanism of bonducellin, a homoisoflavonoid from Caesalpinia bonducella, against polycystic ovary syndrome. Tradit Med Res. 2025;10(11):65.
- [3]. Zengin G, et al. Chemical composition, biological properties and bioinformatics analysis of two Caesalpina species: A new light in the road from nature to pharmacy shelf. Journal of pharmaceutical and biomedical analysis. 2021 May 10;198:114018.
- [4]. Rao YK, et al. Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima. Journal of ethnopharmacology. 2005 Sep 14;100(3):249-53. [Content Brief]
- [5]. Ramamurthy C, et al. Pharmacological Inhibition of METTL3 Suppresses Colon Cancer Proliferation, Migration and Cancer Stemness.
- [6]. Ayyanar CB, et al. Structural, mechanical, thermal, and in-vitro wound healing efficacy of Caesalpinia Bonducella leaf extracts loaded carboxymethylcellulose film. Polymer Bulletin. 2026 Jan;83(1):41.
