845264-92-8
845264-92-8
Chemical Structure
Atacicept
Synonym(s): TACI-Ig; TACI-Fc 5
- CAS No.: 845264-92-8
- Formula:N/A
- Molecular Weight:(70.45 kDa)
IUPAC Name: 3-methyl-4-(trifluoromethyl)-1H-indazole hydrochloride
SMILES: [Atacicept]
Biological Activity: Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease[1][2].
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Atacicept | 99.84% | Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease. | ||||||||||||||||||||
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References
- [1]. Gross JA, et, al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001 Aug;15(2):289-302. [Content Brief]
- [2]. Gross JA, et, al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000 Apr 27;404(6781):995-9. [Content Brief]
