848035-21-2
Chemical Structure
Compound 48/80 trihydrochloride
Synonym(s): C48/80 trihydrochloride
- CAS No.: 848035-21-2
- Formula:C32H48Cl3N3O3
- Molecular Weight:629.10
IUPAC Name: 2,2'-(((2-methoxy-5-(2-(methylamino)ethyl)-1,3-phenylene)bis(methylene))bis(4-methoxy-3,1-phenylene))bis(N-methylethan-1-amine) trihydrochloride
InChIKey: KIAWAQJORBNOIF-UHFFFAOYSA-N
SMILES: CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1.[H]Cl.[H]Cl.[H]Cl
Biological Activity: Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Compound 48/80 trihydrochloride | 99.83% | Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets . | ||||||||||||||||||||
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References
- [1]. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. [Content Brief]
- [2]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. [Content Brief]
- [3]. Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80. [Content Brief]
