848188-18-1
848188-18-1
Chemical Structure
MF266-1
- CAS No.: 848188-18-1
- Formula:C24H17ClF3NO3S
- Molecular Weight:491.91
IUPAC Name: 1-(5-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)pyridin-3-yl)-2,2,2-trifluoroethane-1,1-diol
InChIKey: JCCQFQOPADDTRS-UHFFFAOYSA-N
SMILES: FC(F)(C(O)(C1=CN=CC(C2=C(C3=CC(Cl)=CC=C3OCC4=CC=CC=C4)C=CS2)=C1)O)F
Biological Activity: MF266-1 is a selective E prostanoid receptor 1 (EP1) antagonist with an Ki value of 3.8 nM. MF266-1 also has moderate selectivity for thromboxane A2 receptor (TP). MF266-1 is promising for research of arthritis[1].
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MF266-1 | MF266-1 is a selective E prostanoid receptor 1 (EP1) antagonist with an Ki value of 3.8 nM. MF266-1 also has moderate selectivity for thromboxane A2 receptor (TP). MF266-1 is promising for research of arthritis. | |||||||||||||||||||||
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References
- [1]. Clark P, et al. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. J Pharmacol Exp Ther. 2008 May;325(2):425-34. [Content Brief]
