84873-15-4
Chemical Structure
p-Hydroxyphenethyl trans-ferulate
- CAS No.: 84873-15-4
- Formula:C18H18O5
- Molecular Weight:314.33
IUPAC Name: 4-hydroxyphenethyl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
InChIKey: JMSFLLZUCIXALN-WEVVVXLNSA-N
SMILES: OC(C=C1)=CC=C1CCOC(/C=C/C2=CC(OC)=C(O)C=C2)=O
Biological Activity: p-Hydroxyphenethyl trans-ferulate is an α-glucosidase inhibitor with an IC50 of 19.24 µM against yeast α-glucosidase, and it also possesses antioxidant and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate exhibits weak inhibitory activity against rat lens aldose reductase, competitively binds to the 5-HT7 receptor, and inhibits radioligand binding. p-Hydroxyphenethyl trans-ferulate has DPPH radical scavenging effects, exerts anti-inflammatory activity by inhibiting TPA (HY-18739)-induced mouse ear edema, inhibits advanced glycation end product formation, and demonstrates cancer preventive activity as well as serotonergic activity. p-Hydroxyphenethyl trans-ferulate can be used in research related to diabetes, inflammation, and cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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p-Hydroxyphenethyl trans-ferulate | 99.68% | p-Hydroxyphenethyl trans-ferulate is an α-glucosidase inhibitor with an IC50 of 19.24 µM against yeast α-glucosidase, and it also possesses antioxidant and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate exhibits weak inhibitory activity against rat lens aldose reductase, competitively binds to the 5-HT7 receptor, and inhibits radioligand binding. p-Hydroxyphenethyl trans-ferulate has DPPH radical scavenging effects, exerts anti-inflammatory activity by inhibiting TPA (HY-18739)-induced mouse ear edema, inhibits advanced glycation end product formation, and demonstrates cancer preventive activity as well as serotonergic activity. p-Hydroxyphenethyl trans-ferulate can be used in research related to diabetes, inflammation, and cancer. | ||||||||||||||||||||
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References
- [1]. Park H Y, et al. Constituents of the stem of Angelica gigas with rat lens aldose reductase inhibitory activity[J]. Journal of the Korean Society for Applied Biological Chemistry, 2011, 54(2): 194-199.
- [2]. Deng S, et al. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. Journal of natural products. 2006 Apr;69(4):536-41. [Content Brief]
- [3]. Arciniegas A, et al. Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia[J]. Química Nova, 2017, 40(2): 176-181.
- [4]. Nguyen-Ngoc H, et al. Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds. Phytochemistry. 2022 Oct;202:113300.
