849479-60-3
Chemical Structure
Glycyl-Exatecan
Synonym(s): Glycyl-DX-8951; Exatecan analog 2
- CAS No.: 849479-60-3
- Formula:C26H25FN4O5
- Molecular Weight:492.50
IUPAC Name: 2-amino-N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)acetamide
InChIKey: ZDCWCSNUHWGLRH-QLXKLKPCSA-N
SMILES: NCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
Biological Activity: Glycyl-Exatecan (G-DX-8951) is a Topoisomerase I inhibitor. Glycyl-Exatecan exhibits weaker in vitro cytotoxicity than DX-8951 (HY-13631), and can further release DX-8951 in vivo. Glycyl-Exatecan can be used in studies related to Exatecan metabolism and antitumor drug delivery[1][2].
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Glycyl-Exatecan | Glycyl-Exatecan (G-DX-8951) is a Topoisomerase I inhibitor. Glycyl-Exatecan exhibits weaker in vitro cytotoxicity than DX-8951 (HY-13631), and can further release DX-8951 in vivo. Glycyl-Exatecan can be used in studies related to Exatecan metabolism and antitumor drug delivery. | |||||||||||||||||||||
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References
- [1]. Wente MN, et al. DE-310, a macromolecular prodrug of the topoisomerase-I-inhibitor exatecan (DX-8951), in patients with operable solid tumors. Investigational new drugs. 2005 Aug;23(4):339-47. [Content Brief]
- [2]. Masubuchi N. Pharmacokinetics of DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f, in tumor-bearing mice. Pharmazie. 2004;59:374-377.
