849550-36-3
849550-36-3
Chemical Structure
Tubulin-IN-51
- CAS No.: 849550-36-3
- Formula:C18H18ClF5N6O
- Molecular Weight:464.82
InChIKey: ZUZPCOQWSYNWLU-SECBINFHSA-N
SMILES: FC1=CC(OCCCNC)=CC(F)=C1C2=C(N[C@@H](C(F)(F)F)C)N3N=CN=C3N=C2Cl
Biological Activity: Tubulin-IN-51 is an orally available, potent tubulin inhibitor (IC50 = 31 nM). Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel (HY-B0015) for binding. Tubulin-IN-51 inhibits the binding of Vinblastine (HY-13780) to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis. Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models[1].
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Tubulin-IN-51 | Tubulin-IN-51 is an orally available, potent tubulin inhibitor (IC50 = 31 nM). Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel (HY-B0015) for binding. Tubulin-IN-51 inhibits the binding of Vinblastine (HY-13780) to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis. Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models. | |||||||||||||||||||||
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