850305-06-5
850305-06-5
Chemical Structure
ADL5859
- CAS No.: 850305-06-5
- Formula:C24H28N2O3
- Molecular Weight:392.49
IUPAC Name: N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidin]-4-yl)benzamide
InChIKey: OPIKUXLJQFYMSC-UHFFFAOYSA-N
SMILES: O=C(N(CC)CC)C1=CC=C(C2=CC3(CCNCC3)OC4=C2C(O)=CC=C4)C=C1
Biological Activity: ADL-5859 is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 can be used for the research of pain[1][2].
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ADL5859 | ADL-5859 is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 can be used for the research of pain. | |||||||||||||||||||||
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References
- [1]. Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859) J. Med. Chem., 2008, 51 (19), pp 5893-5896
- [2]. Le Bourdonnec B, et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859). J Med Chem. 2008 Oct 9;51(19):5893-6. [Content Brief]
