850824-74-7
850824-74-7
Chemical Structure
TopBP1-IN-3
- CAS No.: 850824-74-7
- Formula:C27H26N2O4
- Molecular Weight:442.51
InChIKey: HXRUWPWCBPRHEV-UHFFFAOYSA-N
SMILES: OC1=C(C2=CC=CC=C2)C=C(OC(C=C3CN4CCN(C5=CC=C(OC)C=C5)CC4)=O)C3=C1
Biological Activity: TopBP1-IN-3 is an inhibitor of the TopBP1 BRCT7/8 domain. TopBP1-IN-3 disrupts the BRCT7/8-dependent interactions between TopBP1 and E2F1, mutp53, MIZ1, PLK1, and CIP2A, without affecting its protein binding mediated by other BRCT domains. TopBP1-IN-3 can be used for the research of ovarian cancer and breast cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TopBP1-IN-3 | TopBP1-IN-3 is an inhibitor of the TopBP1 BRCT7/8 domain. TopBP1-IN-3 disrupts the BRCT7/8-dependent interactions between TopBP1 and E2F1, mutp53, MIZ1, PLK1, and CIP2A, without affecting its protein binding mediated by other BRCT domains. TopBP1-IN-3 can be used for the research of ovarian cancer and breast cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
