85273-95-6
85273-95-6
Chemical Structure
ICI 169369 free base
- CAS No.: 85273-95-6
- Formula:C19H20N2S
- Molecular Weight:308.44
IUPAC Name: N,N-dimethyl-2-((3-phenylquinolin-2-yl)thio)ethan-1-amine
InChIKey: HYOLQGVNMQNERE-UHFFFAOYSA-N
SMILES: CN(C)CCSC1=NC2=CC=CC=C2C=C1C3=CC=CC=C3
Biological Activity: ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats[1][2][3][4].
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ICI 169369 free base | ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats. | |||||||||||||||||||||
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References
- [1]. Thompson CJ, et al. The effects of the specific serotonin antagonist ICI 169,369 on the pituitary hormone response to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf). 1992 Mar;36(3):235-40. [Content Brief]
- [2]. Blackburn TP, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150(3):247-56. [Content Brief]
- [3]. Kaumann A J, et al. ICI 169,369 selectively blocks 5-hydroxytryptamine2 receptors and lowers portal pressure in portal hypertensive rats[J]. Gastroenterology, 1988, 95(6): 1601-1606. [Content Brief]
- [4]. Blackburn TP, et al. Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist. Eur J Pharmacol. 1990 May 16;180(2-3):229-37. [Content Brief]
