85273-96-7
85273-96-7
Chemical Structure
ICI 169369
- CAS No.: 85273-96-7
- Formula:C19H21ClN2S
- Molecular Weight:344.90
IUPAC Name: N,N-dimethyl-2-((3-phenylquinolin-2-yl)thio)ethan-1-amine hydrochloride
InChIKey: XMRXKCIELMKQPF-UHFFFAOYSA-N
SMILES: CN(C)CCSC1=NC2=CC=CC=C2C=C1C3=CC=CC=C3.Cl
Biological Activity: ICI 169369 is an orally active, specific serotonin and 5-HT2/5-HT1C receptor competitive antagonist. ICI 169369 exhibits Ki values of 1.79 x 10−8 and 1.58 x 10−6 M for 5-HT2 and 5-HT1, respectively[1][2].
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ICI 169369 | ICI 169369 is an orally active, specific serotonin and 5-HT2/5-HT1C receptor competitive antagonist. ICI 169369 exhibits Ki values of 1.79 x 10−8 and 1.58 x 10−6 M for 5-HT2 and 5-HT1, respectively. | |||||||||||||||||||||
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References
- [1]. D S Millson, et al. The effects of a 5-HT2 receptor antagonist (ICI 169,369) on changes in waking EEG, pupillary responses and state of arousal in human volunteers. Br J Clin Pharmacol. 1991 Oct;32(4):447-54. [Content Brief]
- [2]. T P Blackburn, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150(3):247-56. [Content Brief]
