85379-09-5
Chemical Structure
AJ-76
Synonym(s): (+)-AJ 76; (1S,2R)-AJ 76
- CAS No.: 85379-09-5
- Formula:C15H23NO
- Molecular Weight:233.35
IUPAC Name: (1S,2R)-5-methoxy-1-methyl-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
InChIKey: YGHLYBIUVOLKCV-SMDDNHRTSA-N
SMILES: CCCN[C@H]1[C@@H](C)C2=C(C(OC)=CC=C2)CC1
Biological Activity: AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor[1].
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AJ-76 | AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor. | |||||||||||||||||||||
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