857758-13-5
857758-13-5
Chemical Structure
12R-LOX-IN-1
- CAS No.: 857758-13-5
- Formula:C15H11NO2
- Molecular Weight:237.25
InChIKey: FSGLFVYHNDDHEE-UHFFFAOYSA-N
SMILES: OC1=CC=C(N=C(C2=CC=CC=C2O)C=C3)C3=C1
Biological Activity: 12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].
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12R-LOX-IN-1 | 12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research. | |||||||||||||||||||||
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