858747-13-4
Chemical Structure
DRAinh-A250
- CAS No.: 858747-13-4
- Formula:C20H17BrO5
- Molecular Weight:417.26
IUPAC Name: 2-(7-((3-bromobenzyl)oxy)-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetic acid
InChIKey: STHJGDCGBDTTHP-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C=CC(OCC=3C=CC=C(Br)C3)=C2C)C(=C1CC(=O)O)C
Biological Activity: DRAinh-A250 is an orally active inhibitor of mouse and human SLC26A3 (DRA). DRAinh-A250 inhibits SLC26A3-mediated anion transport, blocks colonic fluid absorption, reduces luminal fluid alkalization in the distal colonic loops of mice, and alleviates Loperamide (HY-156131)-induced constipation in wild-type and cystic fibrosis mice. DRAinh-A250 can be used in the research of constipation and cystic fibrosis-related constipation[1][2].
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DRAinh-A250 | DRAinh-A250 is an orally active inhibitor of mouse and human SLC26A3 (DRA). DRAinh-A250 inhibits SLC26A3-mediated anion transport, blocks colonic fluid absorption, reduces luminal fluid alkalization in the distal colonic loops of mice, and alleviates Loperamide (HY-156131)-induced constipation in wild-type and cystic fibrosis mice. DRAinh-A250 can be used in the research of constipation and cystic fibrosis-related constipation. | |||||||||||||||||||||
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References
- [1]. Lee S, et al. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. Journal of medicinal chemistry. 2019 Sep 12;62(17):8330-8337. [Content Brief]
- [2]. Haggie PM, et al. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI insight. 2018 Jul 26;3(14):e121370.
