859498-05-8
859498-05-8
Chemical Structure
AGN 205728
- CAS No.: 859498-05-8
- Formula:C29H27NO3
- Molecular Weight:437.53
IUPAC Name: 4-((1E,3E)-3-(8,8-dimethyl-5-(p-tolyl)-7,8-dihydronaphthalen-2-yl)-3-(hydroxyimino)prop-1-en-1-yl)benzoic acid
InChIKey: AUKGBKLQWDXBEP-FSLFYVJCSA-N
SMILES: CC(C=C1)=CC=C1C2=CCC(C)(C)C3=C2C=CC(C(/C=C/C4=CC=C(C(O)=O)C=C4)=N/O)=C3
Biological Activity: AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 can inhibit abnormal proliferation of leukemia cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AGN 205728 | 98.62% | AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 can inhibit abnormal proliferation of leukemia cells. | ||||||||||||||||||||
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References
- [1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.
- [2]. Watts JM, et al. A Case of AML Characterized by a Novel t(4;15)(q31;q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy. Int J Mol Sci. 2017 Jul 11;18(7):1492. [Content Brief]
