86111-11-7
86111-11-7
Chemical Structure
D 15414
- CAS No.: 86111-11-7
- Formula:C17H17NO2
- Molecular Weight:267.32
InChIKey: BXTNOIWYTWIPEL-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=C(C)C3=CC(O)=CC=C3N2CC)C=C1
Biological Activity: D 15414 is an estrogen receptor ligand and the hydroxylated metabolite of Zindoxifene (HY-106056). D 15414 binds to estrogen receptors and mediates estrogen-like cellular responses. D 15414 stimulates prolactin production, progesterone receptor synthesis and cancer cell proliferation. D 15414 inhibits the growth of hormone-dependent human breast cancer cells. D 15414 can be used in research related to breast cancer and hormone-dependent human breast cancer[1][2].
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D 15414 | D 15414 is an estrogen receptor ligand and the hydroxylated metabolite of Zindoxifene (HY-106056). D 15414 binds to estrogen receptors and mediates estrogen-like cellular responses. D 15414 stimulates prolactin production, progesterone receptor synthesis and cancer cell proliferation. D 15414 inhibits the growth of hormone-dependent human breast cancer cells. D 15414 can be used in research related to breast cancer and hormone-dependent human breast cancer. | |||||||||||||||||||||
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References
- [1]. Robinson SP, et al. In vitro estrogenic actions in rat and human cells of hydroxylated derivatives of D16726 (zindoxifene), an agent with known antimammary cancer activity in vivo. Cancer research. 1988 Feb 15;48(4):784-7. [Content Brief]
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[2]. von Angerer, E. (1984). Development of new drugs for endocrine tumour chemotherapy. Cancer treatment reviews, 11, 147-153.
