861212-49-9
Chemical Structure
HIF-2α-IN-17
- CAS No.: 861212-49-9
- Formula:C17H14FN3O2
- Molecular Weight:311.31
IUPAC Name: methyl 4-((8,9-dimethoxy-2-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)butanoate
InChIKey: GNDAIDWQWRJDQB-UHFFFAOYSA-N
SMILES: CCN1C(NC(C2=CC=C(F)C=C2)=O)=C3C=CC=CC3=NC1=O
Biological Activity: HIF-2α-IN-17 is a selective hypoxia-inducible factor 2α (HIF2α) inhibitor that binds to the PAS-B domain of HIF2α. HIF-2α-IN-17 disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α. HIF-2α-IN-17 exhibits antitumor activity and induces apoptosis in cancer cells. HIF-2α-IN-17 is applicable for research on cancers such as clear cell renal cell carcinoma[1].
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HIF-2α-IN-17 | HIF-2α-IN-17 is a selective hypoxia-inducible factor 2α (HIF2α) inhibitor that binds to the PAS-B domain of HIF2α. HIF-2α-IN-17 disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α. HIF-2α-IN-17 exhibits antitumor activity and induces apoptosis in cancer cells. HIF-2α-IN-17 is applicable for research on cancers such as clear cell renal cell carcinoma. | |||||||||||||||||||||
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