862377-27-3
862377-27-3
Chemical Structure
(2S,3S,11bR)-Dihydrotetrabenazine
Synonym(s): (2S,3S,11bR)-DHTBZ
- CAS No.: 862377-27-3
- Formula:C19H29NO3
- Molecular Weight:319.44
SMILES: COC1=C(OC)C=C2CCN(C[C@@H]([C@H](C3)O)CC(C)C)[C@@]3([H])C2=C1
Biological Activity: (2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders[1].
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(2S,3S,11bR)-Dihydrotetrabenazine | (2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders. | |||||||||||||||||||||
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