862583-15-1
862583-15-1
Chemical Structure
Gastrazole
Synonym(s): JB95008
- CAS No.: 862583-15-1
- Formula:C34H32FN5Na2O7
- Molecular Weight:687.63
IUPAC Name: sodium (S)-5-(2-(5-((cycloheptylmethyl)carbamoyl)-1H-benzo[d]imidazole-6-carboxamido)-3-(2-fluorophenyl)propanamido)isophthalate
InChIKey: VHAXHRARUCKASM-UJXPALLWSA-L
SMILES: O=C(C(C=C(NC=N1)C1=C2)=C2C(NCC3CCCCCC3)=O)N[C@H](C(NC4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)=O)CC(C=CC=C5)=C5F
Biological Activity: Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2].
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Gastrazole | Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer. | |||||||||||||||||||||
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References
- [1]. Chau I, et, al. Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15. [Content Brief]
- [2]. Rudholm T, et, al. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009 Jan 8;152(1-3):8-12. [Content Brief]
