862909-67-9
862909-67-9
Chemical Structure
Epiboxidine hydrochloride
- CAS No.: 862909-67-9
- Formula:C10H15ClN2O
- Molecular Weight:214.69
IUPAC Name: 5-((1R,2S,4S)-7-azabicyclo[2.2.1]heptan-2-yl)-3-methylisoxazole hydrochloride
InChIKey: NSMIYECGCNTSSS-CTERPIQNSA-N
SMILES: CC1=NOC([C@@H]2[C@@H]3N[C@@H](CC3)C2)=C1.[H]Cl
Biological Activity: Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Epiboxidine hydrochloride | Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(±)-Epibatidine | (±)-Epibatidine (CMI 545) is a neuronal nicotinic acetylcholine receptor (nAChR) agonist that targets brain nicotinic receptors, thereby inhibiting afferent micturition pathways and sensory pathways, consequently suppressing the micturition reflex and mediating antihyperalgesic effects. (±)-Epibatidine can be used in the study of trigeminal neuralgia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ABT-418 hydrochloride | 99.37% | ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
L-670,548 | L-670,548 is an active compound. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Epiboxidine | Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ABT-418 | ABT-418 is a selective neuronal nicotinic acetylcholine receptor ligand with activity in improving spatial memory. ABT-418 administered before training can significantly reduce the spatial discrimination deficit caused by ventricular damage. ABT-418 is considered to be a potential treatment for attention deficit disorder. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Epibatidine | Epibatidine is a nicotinic acetylcholine receptor (nAChR) agonist, with an IC50 of 70 pM, a Ki of 43 pM for rat nAChR, a Kd range of 1.5-60 nM for human α7 nAChR, a Kd of 15 nM for rat α4β2 nAChR, and a Kd of 0.5 μM for rat α3β4 nAChR. Epibatidine selectively activates central nAChRs and binds to muscarinic acetylcholine receptors (mAChR). It is used in research on pain, Alzheimer's disease, Parkinson's disease, and schizophrenia-related pain. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Betovumeline | Betovumeline is the agonist for muscarinic receptor and can be used for researchs of neurological disorders. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Betovumeline hydrochloride | 99.65% | Betovumeline hydrochloride is the agonist for muscarinic receptor and can be used for researchs of neurological disorders. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Ceritinib impurity 5 | 98.0% | Ceritinib impurity 5 is an impurity of Ceritinib (HY-15656). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4,5,6,7-Tetrahydrobenzo[d]isoxazol-5-amine hydrochloride | 99.97% | 4,5,6,7-Tetrahydrobenzo[d]isoxazol-5-amine hydrochloride is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
