863238-52-2
863238-52-2
Chemical Structure
Sal-AMP
- CAS No.: 863238-52-2
- Formula:C17H18N5O9P
- Molecular Weight:467.33
InChIKey: AESBJQJIAHTCHE-XNIJJKJLSA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OC(C4=CC=CC=C4O)=O)(O)=O)O3
Biological Activity: Sal-AMP is an acyl-adenylate intermediate. Sal-AMP can be loaded by MbtA on to the thiolation domain of MbtB. Sal-AMP can be used in tuberculosis research[1][2].
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Sal-AMP | Sal-AMP is an acyl-adenylate intermediate. Sal-AMP can be loaded by MbtA on to the thiolation domain of MbtB. Sal-AMP can be used in tuberculosis research. | |||||||||||||||||||||
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References
- [1]. Duckworth BP, et al. Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis. ACS Chem Biol. 2012 Oct 19;7(10):1653-8. [Content Brief]
- [2]. Ferguson L, et al. Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA. ChemMedChem. 2019 Oct 4;14(19):1735-1741. [Content Brief]
