86363-50-0
Chemical Structure
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol
Synonym(s): 9,11-Dehydroergosterol peroxide;9(11)-DHEP
- CAS No.: 86363-50-0
- Formula:C28H42O3
- Molecular Weight:426.63
IUPAC Name: (3S,5S,8S,10R,13R,14R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-1,3,4,10,12,13,14,15,16,17-decahydro-2H-5,8-epidioxycyclopenta[a]phenanthren-3-ol
InChIKey: FWPYIYVSYQRISA-LEOBWYFPSA-N
SMILES: C[C@@]1(CC[C@@H]2O)C([C@]3(C=C[C@]1(C2)OO3)[C@]4([H])CC[C@]5([H])[C@H](C)/C=C/[C@H](C)C(C)C)=CC[C@@]45C
Biological Activity: 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2].
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5,8-Epidioxyergosta-6,9(11),22-trien-3-ol | 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis. | |||||||||||||||||||||
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References
- [1]. Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9(11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29(4):755-759. [Content Brief]
- [2]. Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18(1):938-944. [Content Brief]
