864873-81-4
Chemical Structure
KMUP-4
- CAS No.: 864873-81-4
- Formula:C19H23N7O4
- Molecular Weight:413.43
IUPAC Name: 1,3-dimethyl-7-(2-(4-(2-nitrophenyl)piperazin-1-yl)ethyl)-3,7-dihydro-1H-purine-2,6-dione
InChIKey: GHCXHWXSBNBFPF-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C(N1C)=O)C)N=CN2CCN3CCN(CC3)C4=C(C=CC=C4)[N+]([O-])=O
Biological Activity: KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases[1].
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KMUP-4 | KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases. | |||||||||||||||||||||
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