865451-66-7
Chemical Structure
R1663
- CAS No.: 865451-66-7
- Formula:C24H21ClF3N5O3
- Molecular Weight:519.90
IUPAC Name: (3R,4R)-N3-(5-chloropyridin-2-yl)-1-(2,2-difluoroethyl)-N4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)pyrrolidine-3,4-dicarboxamide
InChIKey: DVMCMTVFXINJGW-IRXDYDNUSA-N
SMILES: O=C([C@H]1CN(CC(F)F)C[C@@H]1C(NC2=CC=C(N3C=CC=CC3=O)C=C2F)=O)NC4=NC=C(Cl)C=C4
Biological Activity: R1663 is a factor Xa inhibitor with anticoagulant activity. R1663 does not affect bleeding time. The pharmacodynamic effects (such as inhibition of thrombin generation) and plasma concentrations of R1663 are dose-dependent. R1663 prolongs clotting time in a concentration-dependent manner and inhibits the peak height of thrombin generation and endogenous thrombin potential[1].
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R1663 | R1663 is a factor Xa inhibitor with anticoagulant activity. R1663 does not affect bleeding time. The pharmacodynamic effects (such as inhibition of thrombin generation) and plasma concentrations of R1663 are dose-dependent. R1663 prolongs clotting time in a concentration-dependent manner and inhibits the peak height of thrombin generation and endogenous thrombin potential. | |||||||||||||||||||||
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