865795-23-9
Chemical Structure
Buntanetap L-Tartrate
Synonym(s): (+)-Phenserine L-Tartrate; ANVS401 L-Tartrate
- CAS No.: 865795-23-9
- Formula:C24H29N3O8
- Molecular Weight:487.50
InChIKey: XKKPTCVQEJZDGT-WXJUTALTSA-N
SMILES: CN1[C@@](N(C)CC2)([H])[C@@]2(C)C3=C1C=CC(OC(NC4=CC=CC=C4)=O)=C3.OC([C@H](O)[C@@H](O)C(O)=O)=O
Biological Activity: Buntanetap L-Tartrate (Phenserine L-Tartrate) is a selective AChE inhibitor (IC50 = 22.2 nM). Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Buntanetap L-Tartrate | 98.93% | Buntanetap L-Tartrate (Phenserine L-Tartrate) is a selective AChE inhibitor (IC50 = 22.2 nM). Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Fang C, et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. J Prev Alzheimers Dis. 2023;10(1):25-33. [Content Brief]
- [2]. Chen XQ, et al. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 7;13(12):2109. [Content Brief]
- [3]. Brossi A , Pei XF Greig NH (1996) Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties. Australian Journal of Chemistry 49, 171-181.
- [4]. Fang, C., et al., (2023). Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. The journal of prevention of Alzheimer's disease, 10(1), 25–33. [Content Brief]
