86761-38-8
Chemical Structure
Ganciclovir triphosphate
Synonym(s): GCV-TP
- CAS No.: 86761-38-8
- Formula:C9H16N5O13P3
- Molecular Weight:495.17
IUPAC Name: 2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl tetrahydrogen triphosphate
InChIKey: OBABDJMYPMAQEP-UHFFFAOYSA-N
SMILES: O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO
Biological Activity: Ganciclovir triphosphate (GCV-TP) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer[1][2][3].
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Ganciclovir triphosphate | Ganciclovir triphosphate (GCV-TP) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer. | |||||||||||||||||||||
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References
- [1]. Yi QY, et al. HSV‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncology reports. 2018 Aug;40(2):682-692. [Content Brief]
- [2]. Rubsam LZ, et al. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res. 1999 Feb 1;59(3):669-75. [Content Brief]
- [3]. Sawdon AJ, et al. Polymeric Nanovectors Incorporated with Ganciclovir and HSV- Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy. Molecules (Basel, Switzerland). 2021 Mar 21;26(6):1759. [Content Brief]
