86828-69-5
Chemical Structure
Poly(deoxyadenylic-thymidylic) acid sodium
Synonym(s): Poly(dA:dT) sodium
- CAS No.: 86828-69-5
- Formula:(C10H15N2O8P.C10H14N5O6P)x.xNa
- Molecular Weight:N/A
SMILES: O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2O)([H])O[C@@H]2CO[P](O)(O)=O.NC3=C4C(N([C@](C[C@@H]5O)([H])O[C@@H]5CO[P](O)(O)=O)C=N4)=NC=N3.[Na].[x].[x]
Biological Activity: Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase[1][2][3].
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Poly(deoxyadenylic-thymidylic) acid sodium | Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase. | |||||||||||||||||||||
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References
- [1]. Graham EM, et al. Effect of gestational age and hypoxia on activity of ribonucleic acid polymerase in fetal guinea pig brain. Am J Obstet Gynecol. 2001;184(4):736-742. [Content Brief]
- [2]. Zhang Z, et al. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol. 2011;12(10):959-965. Published 2011 Sep 4. [Content Brief]
- [3]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013;339(6121):826-830. [Content Brief]
