870768-70-0
870768-70-0
Chemical Structure
IMB-808
- CAS No.: 870768-70-0
- Formula:C18H15F3N2O4
- Molecular Weight:380.32
IUPAC Name: N-methyl-N-(2-oxo-2-((2,3,4-trifluorophenyl)amino)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide
InChIKey: XITZPIXICJOKTF-UHFFFAOYSA-N
SMILES: O=C(N(CC(NC1=CC=C(C(F)=C1F)F)=O)C)C2=CC=C3OCCOC3=C2
Biological Activity: IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used for the study of atherosclerosis research[1].
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IMB-808 | 99.84% | IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used for the study of atherosclerosis research. | ||||||||||||||||||||
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