871824-55-4
871824-55-4
Chemical Structure
JNJ-26489112
- CAS No.: 871824-55-4
- Formula:C9H11ClN2O4S
- Molecular Weight:278.71
InChIKey: KXSAIQPPGSSNKX-ZETCQYMHSA-N
SMILES: O=S(N)(NC[C@@H]1OC2=CC=C(Cl)C=C2OC1)=O
Biological Activity: JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na+ channels and N-type Ca2+ channels, and is effective as a K+ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC50=35 μM) and CA-I (18 μM)[1].
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JNJ-26489112 | 99.31% | JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na+ channels and N-type Ca2+ channels, and is effective as a K+ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC50=35 μM) and CA-I (18 μM). | ||||||||||||||||||||
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