872201-12-2
872201-12-2
Chemical Structure
K114
- CAS No.: 872201-12-2
- Formula:C22H17BrO2
- Molecular Weight:393.27
IUPAC Name: 4,4'-((1E,1'E)-(2-bromo-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
InChIKey: OXPHQQMZTXMEGO-RJTULKDBSA-N
SMILES: BrC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3
Biological Activity: K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI)[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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K114 | 99.59% | K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI). | ||||||||||||||||||||
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References
- [1]. LeVine H 3rd, et al. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry. 2005 Dec 6;44(48):15937-43. [Content Brief]
- [2]. Selmani V, et al. K114 (trans, trans)-bromo-2,5-bis(4-hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils. Protein Sci. 2015 Mar;24(3):420-5. [Content Brief]
