872260-47-4
Chemical Structure
(+/-)-Adomeglivant
Synonym(s): (+/-)-LY2409021
- CAS No.: 872260-47-4
- Formula:C32H36F3NO4
- Molecular Weight:555.63
InChIKey: FASLTMSUPQDLIB-UHFFFAOYSA-N
SMILES: O=C(CCNC(C1=CC=C(C(CCC(F)(F)F)OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)C=C1)=O)O
Biological Activity: (+/-)-Adomeglivant ((+/-)-LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-)-Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-)-Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-)-Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials[1].
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(+/-)-Adomeglivant | (+/-)-Adomeglivant ((+/-)-LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-)-Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-)-Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-)-Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials. | |||||||||||||||||||||
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