872546-39-9
Chemical Structure
LasR-IN-6
- CAS No.: 872546-39-9
- Formula:C25H19N5O5
- Molecular Weight:469.45
InChIKey: VKQUKVLXPRCYFG-ATVHPVEESA-N
SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1)COC2=CC=C(/C=C(C3=NC4=CC=CC=C4N3)/C#N)C=C2OC
Biological Activity: LasR-IN-6 is a LasR inhibitor with an IC50 of 0.261 μM, and exhibits antibacterial activity against Pseudomonas aeruginosa. LasR-IN-6 stably binds to the active site of LasR via hydrophobic interactions, disrupts receptor dimerization, and interferes with quorum sensing. LasR-IN-6 inhibits protease production, biofilm formation, twitching motility and swarming motility in Pseudomonas aeruginosa. LasR-IN-6 can be used in studies related to Pseudomonas aeruginosa infection[1].
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LasR-IN-6 | LasR-IN-6 is a LasR inhibitor with an IC50 of 0.261 μM, and exhibits antibacterial activity against Pseudomonas aeruginosa. LasR-IN-6 stably binds to the active site of LasR via hydrophobic interactions, disrupts receptor dimerization, and interferes with quorum sensing. LasR-IN-6 inhibits protease production, biofilm formation, twitching motility and swarming motility in Pseudomonas aeruginosa. LasR-IN-6 can be used in studies related to Pseudomonas aeruginosa infection. | |||||||||||||||||||||
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