87272-20-6
87272-20-6
Chemical Structure
MEDICA16
- CAS No.: 87272-20-6
- Formula:C20H38O4
- Molecular Weight:342.51
IUPAC Name: 3,3,14,14-tetramethylhexadecanedioic acid
InChIKey: HYSMCRNFENOHJH-UHFFFAOYSA-N
SMILES: O=C(O)CC(C)(C)CCCCCCCCCCC(C)(C)CC(O)=O
Biological Activity: MEDICA16 is an orally active acetyl-CoA carboxylase and ATP-citrate lyase inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MEDICA16 | 98.0% | MEDICA16 is an orally active acetyl-CoA carboxylase and ATP-citrate lyase inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity. | ||||||||||||||||||||
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MEDICA16 (Standard) | ≥98% | MEDICA16 (Standard) is the analytical standard of MEDICA16 (HY-P1123). This product is intended for research and analytical applications. MEDICA16 is an orally active acetyl-CoA carboxylase and ATP-citrate lyase inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity. | ||||||||||||||||||||
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References
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[1]. Laura L Atkinson, et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes. 2002 May;51(5):1548-55.
[Content Brief] - [2]. Rose-Kahn G, et al. Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16). Biochim Biophys Acta. 1990;1042(2):259-264. [Content Brief]
- [3]. Atkinson LL, et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes. 2002 May;51(5):1548-55. [Content Brief]
