872879-86-2
872879-86-2
Chemical Structure
CCR5 antagonist 4
- CAS No.: 872879-86-2
- Formula:C31H43F2N3O5S2
- Molecular Weight:639.82
IUPAC Name: (R)-N-(1-(3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidin-4-yl)propyl)piperidin-4-yl)-N-ethyl-2-(4-(methylsulfonyl)phenyl)acetamide
InChIKey: QOSMEMHKXNNIGG-SSEXGKCCSA-N
SMILES: O=C(N(C1CCN(CC[C@@H](C2=CC(F)=CC(F)=C2)C3CCN(S(=O)(C)=O)CC3)CC1)CC)CC4=CC=C(S(=O)(C)=O)C=C4
Biological Activity: CCR5 antagonist 4 is an orally active CCR5 antagonist. CCR5 antagonist 4 can be studied in research on rheumatoid arthritis[1][2][3].
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CCR5 antagonist 4 | CCR5 antagonist 4 is an orally active CCR5 antagonist. CCR5 antagonist 4 can be studied in research on rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Cumming, J. G., et al., (2012). Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorganic & medicinal chemistry letters, 22(4), 1655-1659. [Content Brief]
- [2]. Elsby, R., et al., (2011). The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug metabolism and disposition: the biological fate of chemicals, 39(2), 275-282. [Content Brief]
- [3]. Gerlag, D. M., et al., (2010). Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate. Arthritis and rheumatism, 62(11), 3154-3160. [Content Brief]
